Key result
Pregnant women with chronic hypertension had significantly higher median plasma levels of Ang-1 (4,111 vs 2,824 pg/mL) and Ang-2 (5,637 vs 3,345 pg/mL) compared to normotensive controls.
Why the study?
Are plasma Ang-1 and Ang-2 levels elevated in pregnant women with chronic hypertension compared to normotensive pregnant women?
Case-Control (n=105)
No
Are plasma Ang-1 and Ang-2 levels elevated in pregnant women with chronic hypertension compared to normotensive pregnant women?
Maternal plasma Ang-1 and Ang-2 levels are significantly elevated in pregnant women with chronic hypertension compared to normotensive controls at the time of delivery.
Elevated Ang-1/Ang-2 in chronic hypertensive pregnancies may signal vascular imbalance; leaves open biomarker or therapeutic utility pending prospective validation.
Purpose: The aim of this study was to investigate whether plasma angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) concentrations in pregnant women with chronic hypertension are different from those of normotensive pregnant women. Methods: This hospital-based case-control study consisted of 35 pregnant women with chronic hypertension who delivered at Seoul National University Hospital. Normotensive pregnant women (n=70) were selected as controls, matched with maternal age, gestational age at delivery and birthweight. Maternal blood was drawn at the time of admission for delivery and plasma was separated and stored. The plasma Ang-1 and Ang-2 levels were measured by ELISA. Statistical analysis was done with Mann-Whitney U test, Fisher's exact test and Spearman rank correlation test using SPSS. Results: Median (range) maternal age, gestational age and birthweight were 33 years (24-42), 38 weeks (3241), and 3.08 kg (1.13-4.01). Pregnant women with chronic hypertension had significantly higher median Ang1 and Ang-2 levels than normotensive pregnant women (for Ang-1 : median 4,111 pg/mL, range 1,415-30,172 vs. median 2,824 pg/mL range 662-14,512, P=0.015, for Ang-2 : median 5,637 pg/mL, range 1,131-29,327 vs. median 3,345 pg/mL, range 609-24,467, P=0.039). Conclusion: Maternal plasma Ang-1 and Ang-2 levels were elevated in pregnant women with chronic hypertension compared with normotensive pregnant women. Further study is needed to determine if this change is a cause or a compensatory mechanism to chronic hypertension.
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Kim et al. (2015) conducted a case-control in Chronic hypertension in pregnancy (n=105). Chronic hypertension vs. Normotensive pregnant women was evaluated on Plasma Angiopoietin-1 (Ang-1) level (pg/mL) (p=0.015). Pregnant women with chronic hypertension had significantly higher median plasma levels of Ang-1 (4,111 vs 2,824 pg/mL) and Ang-2 (5,637 vs 3,345 pg/mL) compared to normotensive controls.
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