September 1, 1991The Journal of Clinical Endocrinology & Metabolism

Measurement of Individual Plasma Angiotensins in Normal Pregnancy and Pregnancy-Induced Hypertension*

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Population

86 women, including 20 nonpregnant women, 17 women with normal pregnancy, and 49 with pregnancy-induced…

Design

Cross-sectional

Authors

MHMyriam HanssensLeiden University MKMarc J. N. C. KeirseLeiden University BSBernard SpitzKU Leuven

Discussion

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Implication

Elevated ANG-(1-8) marks normal pregnancy; cross-sectional data leave open its causal role or therapeutic targeting in pregnancy-induced hypertension.

Structured PICO

Population

86 women, including 20 nonpregnant women, 17 women with normal pregnancy, and 49 with pregnancy-induced hypertension.

Outcome

Plasma levels of individual angiotensin peptides (ANG-(1-8), ANG-(4-8), ANG-(2-8), ANG-(3-8)) measured by HPLC-RIAsurrogate

The increase in ANG-II levels in normal pregnancy is predominantly due to the active ANG-(1-8) octapeptide, while lower levels in pregnancy-induced hypertension relate to lower ANG-(1-8) levels.

Cite This Study

Hanssens et al. (1991) studied this question.

synapsesocial.com/papers/6a8512de6a07aabc6a54dafd https://doi.org/10.1210/jcem-73-3-489

Topics

Hypertension management

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Implication

Elevated ANG-(1-8) marks normal pregnancy; cross-sectional data leave open its causal role or therapeutic targeting in pregnancy-induced hypertension.