Key result
Actinomycin D inhibited the production of foot-and-mouth disease virus-induced RNA polymerase in baby hamster kidney cells by up to 85% when added 90 minutes before infection.
Population
Baby hamster kidney cells infected with foot-and-mouth disease virus
Comparison
Actinomycin D vs Untreated cells
Design
Preclinical
Authors
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Does not support clinical use of actinomycin D; leaves open polymerase dependency in FMDV replication models.
Actinomycin D inhibits virus-induced RNA polymerase formation in foot-and-mouth disease virus-infected cells without consistently inhibiting virus production.
Polatnick et al. (1967) studied Foot-and-Mouth Disease Virus infection. Actinomycin D vs. Untreated cells was evaluated on Production of foot-and-mouth disease virus-induced RNA polymerase. Actinomycin D inhibited the production of foot-and-mouth disease virus-induced RNA polymerase in baby hamster kidney cells by up to 85% when added 90 minutes before infection.
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