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Rifampicin and actinomycin D inhibit the replication of poliovirus and foot-and-mouth disease virus in cell cultures.
SUMMARY Reduced yields of poliovirus and foot-and-mouth disease virus are obtained in suspended cell cultures in the presence of rifampicin. The effect of the drug appears to be related to virus replication and not to a toxic effect on the host cells. The inhibition is reversed upon removal of the drug. The replication of both picornaviruses in suspended cultures is affected by actinomycin D, but not by mitomycin C.
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Grado et al. (1973) studied this question.
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