Key result
Pharmacokinetic-based total intravenous anaesthesia with remifentanil and propofol provided stable haemodynamics and allowed safe early extubation (150 ± 18 min) after coronary surgery.
Why the study?
Does pharmacokinetic-guided total intravenous anaesthesia with remifentanil and propofol provide adequate anaesthesia and allow early extubation in patients undergoing on-pump coronary bypass surgery?
Population
32 patients undergoing on-pump coronary bypass surgery
Design
Cohort
Follow-up
Up to 4 hours after tracheal extubation
Authors
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Supports pharmacokinetic-guided TIVA for stable hemodynamics and early extubation after on-pump CABG; leaves open confirmation versus inhalational techniques in RCTs.
Does pharmacokinetic-guided total intravenous anaesthesia with remifentanil and propofol provide adequate anaesthesia and allow early extubation in patients undergoing on-pump coronary bypass surgery?
Pharmacokinetic-based total intravenous anaesthesia with remifentanil and propofol provides stable intraoperative haemodynamics and facilitates safe, early extubation after on-pump coronary bypass surgery.
Guarracino et al. (2005) studied surgical myocardial revascularization (n=32). Pharmacokinetic-guided total intravenous anaesthesia with remifentanil and propofol was evaluated on anaesthetic efficacy, haemodynamic effects, impact on extubation of the trachea and analgesia after operation. Pharmacokinetic-based total intravenous anaesthesia with remifentanil and propofol provided stable haemodynamics and allowed safe early extubation (150 ± 18 min) after coronary surgery.
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