Key result
Neutralizing antibodies against western equine encephalomyelitis were detected in the cerebrospinal fluid of 26.2% of convalescent patients and in experimentally inoculated monkeys.
Population
80 convalescent human patients and experimental monkeys
Design
Preclinical
Follow-up
Up to 9 months in humans, up to 5 weeks in monkeys
Authors
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CSF antibody detection warrants clinical caution; leaves open diagnostic utility pending human validation.
Observational (n=80)
Neutralizing antibodies to western equine encephalomyelitis and St. Louis encephalitis viruses can be detected in the blood and cerebrospinal fluid of infected humans and experimentally inoculated monkeys.
B. F. Howitt (1941) conducted an observational in Western equine encephalomyelitis and St. Louis encephalitis (n=80). Infection with western equine encephalomyelitis and/or St. Louis encephalitis viruses was evaluated on Presence of neutralizing antibodies in cerebrospinal fluid. Neutralizing antibodies against western equine encephalomyelitis were detected in the cerebrospinal fluid of 26.2% of convalescent patients and in experimentally inoculated monkeys.
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