Key result
A 21-year-old woman with Hodgkin's disease developed pulseless disease (aortic arch syndrome), suggesting a possible relationship to prior radiotherapy.
Case Report (n=1)
No
This case report suggests a possible relationship between radiotherapy for Hodgkin's disease and the development of pulseless disease (aortic arch syndrome).
Alerts to possible radiotherapy-related aortic arch syndrome in Hodgkin survivors; leaves causal link open for confirmation.
THE SIGNS and symptoms of the uncommon condition known as "pulseless disease" (aortic arch syndrome) are dependent on the location of the vascular occlusions and the adequacy of the collateral circulation.1The "subclavian steal syndrome" and signs of carotid artery insufficiency may be appreciated if the appropriate vessels are involved. In addition, claudication of muscles supplied by involved blood vessels may be noted.2,3 A case of a young woman with Hodgkin's disease who developed "pulseless disease" is presented. A possible relationship to radiotherapy given for the treatment of Hodgkin's disease is suggested. Report of a Case A 21-year-old, married, white secretary was referred to the Tumor Service of the US Public Health Service Hospital, Baltimore, on Oct 14, 1953. A chest film taken elsewhere in March 1953 demonstrated mediastinal widening. Supraclavicular lymphadenopathy was detected in October 1953; a lymph node biopsy was diagnostic of Hodgkin's granuloma. Upper extremity
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William J. Heidenberg (1966) conducted a case report in Hodgkin's disease and pulseless disease (n=1). Radiotherapy was evaluated on Development of pulseless disease. A 21-year-old woman with Hodgkin's disease developed pulseless disease (aortic arch syndrome), suggesting a possible relationship to prior radiotherapy.
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