Key result
During hypothermic cardiopulmonary bypass, renal blood flow was positively correlated with systemic blood pressure (r=0.71, P<0.001) and pump flow rate (r=0.69, P<0.001).
Why the study?
How do pump flow rate and systemic blood pressure influence renal function during hypothermic cardiopulmonary bypass?
Population
14 male patients undergoing hypothermic cardiopulmonary bypass (CPB)
Design
Other
Follow-up
During cardiopulmonary bypass
Authors
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May warrant cautious pump flow and pressure management on bypass; hypothesis-generating for renal outcome trials.
Observational (n=14)
How do pump flow rate and systemic blood pressure influence renal function during hypothermic cardiopulmonary bypass?
Effect estimate: r = 0.71 (blood pressure), r = 0.69 (pump flow)
p-value: p=<0.001
Renal autoregulation is lost during hypothermic cardiopulmonary bypass, with renal blood flow primarily determined by pump flow rate and urinary flow by systemic blood pressure.
Andersson et al. (1994) conducted an observational in Hypothermic cardiopulmonary bypass (n=14). Systemic blood flow (pump flow) and arterial blood pressure was evaluated on Renal blood flow (RBF) (r = 0.71 (blood pressure), r = 0.69 (pump flow), p=<0.001). During hypothermic cardiopulmonary bypass, renal blood flow was positively correlated with systemic blood pressure (r=0.71, P<0.001) and pump flow rate (r=0.69, P<0.001).
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