This case report highlights a presentation of severe 5-fluorouracil cardiotoxicity whose mechanism extends beyond the classically recognized coronary vasospasm or acute myocarditis.
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May indicate mechanisms beyond vasospasm or myocarditis in 5-FU cardiotoxicity; hypothesis-generating for mechanistic studies.
Cardiotoxicity is a rare but serious complication of 5-fluorouracil therapy. Coronary vasospasm and, less frequently, acute myocarditis have been identified as underlying mechanisms. We report a case of severe toxicity in a relatively young and fit male patient being treated for metastatic colonic adenocarcinoma displaying characteristics that cannot be explained by either mechanism alone.
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Dalzell et al. (2008) studied this question.
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