Key result
Platelet distribution width was significantly higher in patients with coronary slow flow compared to those with normal coronary flow (16.6% vs. 16.4%, p=0.002), and a PDW > 16.15% predicted coronary slow flow.
Case-Control (n=288)
Single-blind
No
Absolute Event Rate: 16.6% vs 16.4%
p-value: p=0.002
Elevated platelet distribution width, hemoglobin, neutrophil-to-lymphocyte ratio, and red cell distribution width are significantly associated with the presence of coronary slow flow in patients with stable angina.
PDW elevation may identify coronary slow flow risk in stable angina; hypothesis-generating and should not yet change practice.
INTRODUCTION: Coronary slow flow (CSF) is an angiographic phenomenon characterised by the delay of distal vessel opacification in the absence of significant stenosis of the epicardial coronary arteries. Some of the factors playing a role in CSF pathophysiology are increased thrombogenic activity and inflammation. AIM: To examine the relationship between platelet distribution width (PDW) and CSF. MATERIAL AND METHODS: Taking into consideration the exclusion criteria, 136 patients with CSF and 152 patients with normal coronary angiographies (control group) were included in the study. The association between thrombolysis infarction frame count (TFC) in myocardial and laboratory and other clinical parameters were evaluated. RESULTS: The stated parameters were significantly higher in the group with CSF than in the normal coronary angiography group (control group). The PDW (16.6 ±0.7 vs. 16.4 ±0.6, p = 0.002), neutrophil lymphocyte ratio (NLR) (3.1 ±3.4 vs. 2.4 ±1.1, p = 0.027), haemoglobin (Hb) (14.1 ±1.3 vs. 14.7 ±1.1, p < 0.001), and red cell distribution width (RDW) (13.6 ±0.7 vs. 14.1 ±2.8, p = 0.026) were significantly higher in the CSF group than in the control group. Moreover, our study showed that PDW > 16.15 and Hb > 1 3.75 were predictors of the presence of CSF with sensitivities of 83% and 73% and specificities of 40% and 42%, respectively. CONCLUSIONS: This study has demonstrated that compared to normal coronary flow, PDW, Hb, NLR, and RDW are significantly higher in CSF patients. We believe that further studies are needed to clarify the role of PDW and Hb in patients with CSF.
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Özyurtlu et al. (2014) conducted a case-control in Stable angina pectoris with coronary slow flow (n=288). Coronary slow flow vs. Normal coronary flow was evaluated on Platelet distribution width (PDW) (p=0.002). Platelet distribution width was significantly higher in patients with coronary slow flow compared to those with normal coronary flow (16.6% vs. 16.4%, p=0.002), and a PDW > 16.15% predicted coronary slow flow.
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