Key result
Prior infection with a low-virulence feline calicivirus (F-9) completely protected cats from clinical disease following challenge with a virulent strain (0% vs 100% in controls).
Why the study?
Does prior infection with low-virulence feline calicivirus (F-9) prevent disease from virulent feline calicivirus (FPV-255) in cats?
Does prior infection with low-virulence feline calicivirus (F-9) prevent disease from virulent feline calicivirus (FPV-255) in cats?
Absolute Event Rate: 0% vs 100%
Prior infection with a low-virulence feline calicivirus induces heterotypic protective immunity against a virulent strain in cats.
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Hypothesis-generating for heterotypic immunity in cats; leaves open translation to vaccines or other species.
Kahn et al. (1975) studied Feline caliciviral disease (n=8). Aerosol exposure to feline calicivirus of low virulence (F-9 virus) vs. No prior F-9 exposure (susceptible specific-pathogen-free cats) was evaluated on Development of pyrexia, depression, dyspnea, oral ulcers, and severe pneumonia after FPV-255 challenge. Prior infection with a low-virulence feline calicivirus (F-9) completely protected cats from clinical disease following challenge with a virulent strain (0% vs 100% in controls).
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