Key result
Children infected with Vietnamese G1P[8] double-gene reassortant strains experienced severe diarrhea, but it was slightly less severe than in children infected with ordinary G1P[8] strains.
Why the study?
Does infection with G1P[8] double-gene reassortant rotavirus A strains increase the severity of diarrhea compared to ordinary G1P[8] strains in children under two years of age?
Cross-Sectional (n=382)
Yes
Does infection with G1P[8] double-gene reassortant rotavirus A strains increase the severity of diarrhea compared to ordinary G1P[8] strains in children under two years of age?
Vietnamese G1P[8] double-gene reassortant rotavirus A strains originated from a locally circulating G2P[4] strain and caused severe diarrhea, but did not show increased virulence compared to ordinary G1P[8] strains.
This is the authors' abstract. We don't add key points for this paper.
Rotavirus A (RVA) strains, a leading cause of severe gastroenteritis in children worldwide, commonly possess the Wa or DS-1 genotype constellations. During a hospital-based study conducted in Hanoi, Vietnam, in the 2012-2013 rotavirus season, G1P[8] strains with a virtually identical short RNA migration pattern were detected in 20 (14%) of 141 rotavirus-positive samples. Two representatives of these strains were shown by whole-genome sequencing to be double-gene reassortants possessing the genotype constellation of G1-P[8]-I2-R2-C2-M2-A2-N2-T2-E2-H2. Sequencing and a database search revealed that these Vietnamese G1P[8] double-gene reassortant strains shared an immediate ancestor with a locally circulating G2P[4] strain in all of the inner-capsid and non-structural protein genes, whereas they were more closely related in the VP7 and VP4 genes to a Chinese G1P[8] strain and a Chinese G3P[8] strain, respectively, than to locally circulating G1P[8] strains. Despite the marked similarity between Japanese and Thai G1P[8] double-gene reassortant strains, phylogenetic analysis suggested that the Vietnamese and Japanese/Thai G1P[8] double-gene reassortant strains originated from independent reassortment events. Clinically, children infected with Vietnamese G1P[8] double-gene reassortant strains experienced severe diarrhoea, but it was not more severe than that in children infected with ordinary G1P[8] strains. In conclusion, Vietnamese G1P[8] double-gene reassortant strains originated from a locally circulating G2P[4] strain and caused severe diarrhoea, but there was no evidence of increased virulence.
Answers are grounded in this paper and cite their sources.
Reassortant G1P[8] strains linked to severe but not heightened diarrhea severity; leaves open need for prospective surveillance of rotavirus evolution.
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Nakagomi et al. (2016) conducted a cross-sectional in Acute diarrhea (Rotavirus A gastroenteritis) (n=382). G1P[8] double-gene reassortant rotavirus A strains vs. Ordinary G1P[8] rotavirus A strains was evaluated on Severity of diarrhea (Vesikari's 20-point scale) (p=0.0010). Children infected with Vietnamese G1P[8] double-gene reassortant strains experienced severe diarrhea, but it was slightly less severe than in children infected with ordinary G1P[8] strains.
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