Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 1, 2016PLoS ONEOpen Access

Full Genome Characterization of Novel DS-1-Like G8P8 Rotavirus Strains that Have Emerged in Thailand: Reassortment of Bovine and Human Rotavirus Gene Segments in Emerging DS-1-Like Intergenogroup Reassortant Strains

View Full Paper
Ask AI
Bookmark
Share

Key result

Emerging DS-1-like G8P[8] rotavirus strains exhibit a unique genotype driven by complex bovine-human reassortment.

  • n=14

Population

12 novel DS-1-like intergenogroup reassortant rotavirus strains having G8P[8] genotypes identified in stool…

Design

Other

Authors

RTRatana TacharoenmuangNational Institute of Health of ThailandSKSatoshi KomotoOkayama Shoka UniversityRGRatigorn GuntapongNational Institute of Health of Thailand

Discussion

Loading...

Member takes

Implication

Emerging reassortant rotavirus strains warrant enhanced surveillance; leaves open implications for vaccine efficacy in Asia.

Study Design

Type

Observational (n=14)

Structured PICO

P
Population
14 hospitalized children aged 11-54 months with severe rotavirus gastroenteritis in Thailand, whose stool samples were used for full genome sequencing of the virus.
O
Outcome
Full genome characterization and phylogenetic analysis

The study provides the first full genome-based characterization of emerging DS-1-like G8P[8] rotavirus strains in Thailand, revealing complex reassortment between human and animal strains.

Limitations

  • The exact origins of the bovine-like VP7, VP6, VP1, and/or NSP2 genes, and human-like NSP4 genes could not be ascertained due to a lack of sufficient representative reference strains.

Cite This Study

Tacharoenmuang et al. (2016) conducted an observational in Severe diarrhea (Rotavirus infection) (n=14). Rotavirus infection (DS-1-like G8P[8] strains) was evaluated on Genotype constellation and phylogenetic origin of rotavirus strains. Emerging DS-1-like G8P[8] rotavirus strains in Thailand possess a unique genotype constellation generated through complex reassortment events involving bovine and human rotavirus gene segments.

synapsesocial.com/papers/6aa91377b7876cb3302c8e79https://doi.org/10.1371/journal.pone.0165826
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Predominant prevalence of human rotaviruses with the G1P[8] and G8P[8] genotypes with a short RNA profile in 2013 and 2014 in Sukhothai and Phetchaboon provinces, Thailand2016 · 28 citations
  2. 2Prevalence and molecular characterization of G1P[8] human rotaviruses possessing DS‐1‐like VP6, NSP4, and NSP5/6 in Japan2013 · 42 citations
  3. 3Whole Genomic Analysis of Human G12P[6] and G12P[8] Rotavirus Strains that Have Emerged in Myanmar2015 · 32 citations
  4. 4Equine-like G3 rotavirus in Hungary, 2015 – Is it a novel intergenogroup reassortant pandemic strain?2016 · 86 citations
  5. 5G8Rotavirus Strains Isolated in the Democratic Republic of Congo Belong to the DS-1-Like Genogroup2006 · 119 citations