What question did this study set out to answer?

To evaluate whether microalbuminuria, including urinary albumin excretion rates below traditional cutoffs, relates to vascular and cardiac end-organ damage in untreated elderly hypertensive patients.

January 1, 2002Blood PressureOpen Access

Microalbuminuria is Related to Marked End Organ Damage in Previously Untreated, Elderly Hypertensive Patients

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Why the study?

Is microalbuminuria associated with increased end organ damage in previously untreated elderly hypertensive patients?

Population

173 previously untreated elderly hypertensive patients, mean age 67 +/- 4 years, free from diabetes mellitus…

Comparison

Presence of microalbuminuria vs Absence of microalbuminuria

Design

Cross-sectional

Authors

WTW. F. TerpstraPraxis für Humangenetik JMJohan F. MayUniversity Medical Center Groningen ASA. J. SmitErasmus MC Cancer Institute

Discussion

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Implication

Microalbuminuria is independently associated with increased intima media thickness and left ventricular mass in elderly hypertensive patients, suggesting it serves as an early marker for end-organ damage.

Key Points

To evaluate whether microalbuminuria, including urinary albumin excretion rates below traditional cutoffs, relates to vascular and cardiac end-organ damage in untreated elderly hypertensive patients.
Screened 173 previously untreated hypertensive patients (mean age 67 ± 4 years; systolic BP 160–220 mmHg, diastolic BP 95–115 mmHg) without diabetes or clinical atherosclerosis for microalbuminuria (20–300 mg/24 h).
Assessed end-organ damage using B-mode ultrasound for carotid and femoral intima-media thickness and echocardiography for left ventricular mass index, analyzed via linear regression.
Microalbuminuria was present in 8% (14/173) of the hypertensive cohort.
Patients with microalbuminuria had significantly higher intima-media thickness (1.01 ± 0.21 vs. 0.88 ± 0.6 mm, p < 0.05) and increased left ventricular mass index (118 ± 31 vs. 103 ± 22 g/m², p < 0.05) compared to those without it.
Microalbuminuria remained independently associated with intima-media thickness in linear regression analysis alongside age, male sex, and diastolic blood pressure.

Structured PICO

Is microalbuminuria associated with increased end organ damage in previously untreated elderly hypertensive patients?

Population

173 previously untreated elderly hypertensive patients (systolic blood pressure 160-220 mmHg and/or diastolic blood pressure 95-115 mmHg), mean age 67 +/- 4 years, free from diabetes mellitus and clinical atherosclerosis.

Intervention

Presence of microalbuminuria (defined as urinary albumin excretion between 20 and 300 mg/24 h)

Comparator

Absence of microalbuminuria

Outcome

End organ damage determined by intima media thickness (IMT) of carotid and femoral arteries and left ventricular mass indexsurrogate

Cite This Study

Terpstra et al. (2002) studied this question.

synapsesocial.com/papers/6a99f13fe3a0252557de8aed https://doi.org/10.1080/08037050211267

Topics

Hypertension management

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Microalbuminuria is Related to Marked End Organ Damage in Previously Untreated, Elderly Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Microalbuminuria is Related to Marked End Organ Damage in Previously Untreated, Elderly Hypertensive Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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