Key result
Postoperative serum procalcitonin levels ≥0.5 ng/mL at 48 hours were significantly associated with a higher rate of general complications (27.5% vs 6.5%, p=0.023) and longer durations of ICU stay and mechanical ventilation.
Why the study?
Procalcitonin release has been suggested to relate to the type of surgery and cardiopulmonary bypass, but its associations with hemodynamic stability, surgery type, and complications required investigation.
Does serum procalcitonin level predict complications and clinical course in adult patients undergoing open-heart surgery?
Observational (n=76)
No
Does serum procalcitonin level predict complications and clinical course in adult patients undergoing open-heart surgery?
Absolute Event Rate: 27.5% vs 6.5%
p-value: p=0.023
Elevated postoperative procalcitonin levels, particularly at 48 hours, are associated with the development of complications and longer durations of ICU stay, mechanical ventilation, and hospitalization in open-heart surgery patients.
Higher post-op PCT correlated with complications and longer stays; supports further study of monitoring but should not yet change practice.
Aim: The release of procalcitonin (PCT) has been suggested to be related to the type of surgery and cardiopulmonary bypass (CPB). We aimed to investigate the associations of PCT with hemodynamic stability, type of cardiac surgery, and complications.Methods: Our study was conducted in 2015 on 76 adult patients divided into three groups according to types of surgery: group I consisted of coronary artery bypass grafting with CPB, group II consisted of cardiac valve replacement, and group III included left ventricle assist device implantation. The patients’ serum PCT values were measured preoperatively before induction, 24 and 48 hours postoperatively, and when a complication occurred.Results: Preoperative PCT levels of the groups were similar. The PCT level in group I was lowest preoperatively, highest in postoperative 24 hours, and showed a decline postoperatively from 24 hours to 48 hours. In group II, the PCT level was increased in postoperative 24 and 48 hours compared to the preoperative level, and there was no difference between postoperative 24- and 48-hour values. In group III, the PCT level was lowest preoperatively and highest in postoperative 24 hours, while the postoperative 48-hour value was lower than the 24-hour value. Intensive care unit (ICU) stay with a higher P1PCTlevel correlated with longer ICU stay. There were no differences between patients with PCT levels ≥ 0.5 and
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Deniz et al. (2023) conducted an observational in Open heart surgery (n=76). Postoperative serum procalcitonin (PCT) level ≥0.5 ng/mL vs. Postoperative serum procalcitonin (PCT) level <0.5 ng/mL was evaluated on Development of postoperative complications in general (p=0.023). Postoperative serum procalcitonin levels ≥0.5 ng/mL at 48 hours were significantly associated with a higher rate of general complications (27.5% vs 6.5%, p=0.023) and longer durations of ICU stay and mechanical ventilation.
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