Key result
Differences between MDV- and HVT-gA were particularly observed in isoelectric points of the glycosylated or unglycosylated precursor forms.
Biochemical distinctions in gA precursors may guide antigenic mapping; leaves open functional or immunologic consequences.
The steps from the precursor to the processed forms of a secreted glycoprotein (gA) of Marek's disease virus (MDV) and of herpesvirus of turkeys (HVT) were examined by two-dimensional gel electrophoresis of immunoprecipitates from the cell lysate and medium of infected cultures with monoclonal antibodies. Differences between MDV- and HVT-gA were particularly observed in isoelectric points of the glycosylated or unglycosylated precursor forms.
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Ikuta et al. (1985) studied Marek's disease virus and herpesvirus of turkeys infection. Marek's disease virus (MDV) vs. Herpesvirus of turkeys (HVT) was evaluated on Differences in the processing of secreted glycoprotein A (gA). Differences between MDV- and HVT-gA were particularly observed in isoelectric points of the glycosylated or unglycosylated precursor forms.
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