Key result
Surgical liver denervation in conscious rats resulted in a significantly more marked decrease in cardiac index following hemorrhage compared to sham operation (-62% vs -47%; p<0.05).
Why the study?
Does hepatic denervation alter the hemodynamic response to hemorrhage in conscious rats?
Does hepatic denervation alter the hemodynamic response to hemorrhage in conscious rats?
Hepatic nerve function contributes significantly to overall cardiovascular homeostasis during hemorrhage by mediating portal territory vasoconstriction.
May indicate hepatic innervation buffers post-hemorrhage cardiac output in rats; leaves open translation to human shock physiology.
We investigated the effect of liver denervation on cardiovascular homeostasis. Three days after surgical denervation of the liver, hemodynamic studies (radioactive microsphere method) were conducted in conscious rats. The efficacity of the liver denervation procedure was confirmed by a significant decrease in norepinephrine content in various lobes of the liver. Liver denervation did not affect either systemic or splanchnic resting hemodynamics. However, hemorrhage (2 ml per 100 gm body weight) induced a decrease in cardiac index which was significantly more marked in rats with liver denervation (-62 +/- 3%) than in sham-operated rats (-47 +/- 5%; p less than 0.05). This more severe response to hemorrhage may be due to a lack of portal territory vasoconstriction since the fraction of cardiac output reaching portal territory did not decrease during hemorrhage in rats with liver denervation (16 +/- 1% to 14 +/- 1%) but significantly decreased in sham-operated rats (from 15 +/- 1% to 11 +/- 1%, p less than 0.05), this value being significantly lower, after hemorrhage, in sham-operated rats than in denervated rats. The results confirm the lack of tonic neural influence on hepatic circulation during physiological experimental conditions and indicate that hepatic nerve function has a significant contribution to the overall cardiovascular homeostasis.
No takes yet. Share an insight, caveat, or question.
Ozier et al. (1989) studied Hemorrhage. Surgical liver denervation vs. Sham operation was evaluated on Decrease in cardiac index following hemorrhage (p=<0.05). Surgical liver denervation in conscious rats resulted in a significantly more marked decrease in cardiac index following hemorrhage compared to sham operation (-62% vs -47%; p<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: