Key result
Acute ethanol exposure produced concentration-dependent negative inotropic effects in both spontaneously hypertensive and normotensive rats, though the magnitude was attenuated at 25 weeks of age.
Population
Papillary muscles from spontaneously hypertensive rats and Wistar-Kyoto rats at 10 and 25 weeks of age
Comparison
Acute ethanol exposure at clinically relevant… vs Baseline mechanical properties and comparison…
Design
Preclinical
Authors
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Findings from aged hypertensive rats should not alter clinical ethanol guidance; leaves open human translation of age-related cardiac attenuation.
In a rat model, aging combined with hypertension depresses baseline cardiac mechanical properties and attenuates the negative inotropic effects of acute ethanol exposure.
Brown et al. (1996) studied Hypertension. Acute ethanol exposure vs. Baseline / Wistar-Kyoto rats was evaluated on Mechanical parameters (peak tension developed, time to peak tension, time to 90% relaxation, maximal velocities of tension development and tension decline). Acute ethanol exposure produced concentration-dependent negative inotropic effects in both spontaneously hypertensive and normotensive rats, though the magnitude was attenuated at 25 weeks of age.
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