Key result
Black patients with essential hypertension had higher blood pressure and lower plasma renin activity than white patients, with no difference in mean plasma noradrenaline.
Observational (n=100)
This study highlights ethnic differences in the pathophysiology of essential hypertension, showing lower plasma renin activity in black patients compared to white patients.
May inform ethnicity-specific renin assessment in hypertension; leaves open mechanisms of racial BP differences.
100 patients with essential hypertension (77 whites, 23 black) were studied with measurements of plasma noradrenaline concentration and plasma renin activity. Black patients had higher blood pressure than whites. There were no ethnic differences in mean plasma noradrenaline, but plasma renin activity was lower in blacks than whites, and this difference was not related to differences in sodium intake. Plasma noradrenaline increased with age in blacks, and in a white control group. Young white hypertensive patients (< 45 years) had higher plasma noradrenaline than controls, and in white hypertensives plasma noradrenaline was positively correlated with plasma renin.
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Sever et al. (1979) conducted an observational in Essential hypertension (n=100). Black ethnicity vs. White ethnicity was evaluated on Blood pressure, plasma noradrenaline concentration, and plasma renin activity. Black patients with essential hypertension had higher blood pressure and lower plasma renin activity than white patients, with no difference in mean plasma noradrenaline.
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