Key result
The addition of Ca2+ to nicardipine formed a 2:1 drug:Ca2+ sandwich complex with a dissociation constant of 100 microM, inducing a stable synperiplanar conformation.
Population
Nicardipine in acetonitrile solution (in vitro chemical study)
Comparison
Addition of Ca2+ vs Absence of Ca2+
Design
Preclinical
Authors
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Does not alter dihydropyridine use; leaves open a structural Ca2+ role in their mechanism for further study.
Nicardipine forms a stable 2:1 "sandwich" complex with Ca2+ in solution, suggesting a structural role for calcium in the mechanism of action of dihydropyridines.
Belciug et al. (1994) studied this question. Addition of Ca2+ vs. Absence of Ca2+ was evaluated on Conformational features and binding characteristics. The addition of Ca2+ to nicardipine formed a 2:1 drug:Ca2+ sandwich complex with a dissociation constant of 100 microM, inducing a stable synperiplanar conformation.
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