Key result
Plasma levels of coagulation factors (FII, FVII, FVIII, Fg, vWF) were significantly higher in AMI patients younger than 60 years compared to healthy controls (p < 0.01).
Why the study?
Are elevated levels of coagulation factors and inflammatory cytokines associated with the development of acute myocardial infarction in patients younger than 60 years?
Case-Control (n=90)
No
Are elevated levels of coagulation factors and inflammatory cytokines associated with the development of acute myocardial infarction in patients younger than 60 years?
Elevated levels of specific coagulation factors and inflammatory cytokines (TNF-α, IL-6) are associated with acute myocardial infarction in patients younger than 60 years, suggesting a role in its pathogenesis.
Answers are grounded in this paper and cite their sources.
May link coagulation and cytokines to early AMI; hypothesis-generating and requires prospective validation before any clinical use.
Purpose: To investigate the effects of coagulation factors and inflammatory cytokines on acute myocardial infarction (AMI) development in patients younger than 60 years.Methods: In this study, 60 patients admitted to The First Affiliated Hospital of Dalian Medical University (Dalian, China) with AMI and 30 other subjects matched with the patients for age and ethnicity but without AMI were enrolled. Blood samples were collected from the AMI patients and the control subjects after a 12-h fast. Subsequently, the levels of coagulation factors (F) II (FII), VII (FVII), VIII (FVIII), fibrinogen (Fg) and von Willebrand factor (vWF) in plasma were analyzed by enzyme-linked immunosorbent assay (ELISA). The protein expression levels of these coagulation factors were determined by Western blot analysis. Inflammatory factors including C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) and interleukin- 6 (IL-6) were also measured by ELISA.Results: FII, FVII, FVIII, Fg and vWF levels in plasm were significantly higher in AMI patients compared with control subjects (p < 0.01). Furthermore, the protein expression levels of FII, FVII, FVIII, Fg and vWF were also significantly up-regulated in AMI patients compared with those in control subjects. Additionally, no significant difference was observed in CRP between AMI patients and control subjects (p > 0.05). However, TNF-α and IL-6 levels in the plasma of AMI patients were significantly higher than those in control subjects (p < 0.05).Conclusion: The results reveal that the pathogenesis of AMI in patients younger than 60 years might be closely related to the high levels of coagulation factors and inflammatory cytokines in the blood.
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Wang et al. (2016) conducted a case-control in Acute myocardial infarction (n=90). Elevated coagulation factors and inflammatory cytokines vs. Healthy control subjects without AMI was evaluated on Plasma levels of coagulation factors (FII, FVII, FVIII, Fg, vWF) (p=<0.01). Plasma levels of coagulation factors (FII, FVII, FVIII, Fg, vWF) were significantly higher in AMI patients younger than 60 years compared to healthy controls (p < 0.01).
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