Key result
An 11-week-old boy with X-linked agammaglobulinemia and perinatal HIV exposure presented with immunodeficiency-associated vaccine-derived poliovirus serotype 3 and a high viral evolutionary rate.
Why the study?
Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses.
Case Report (n=1)
Highlights the risk of rapid vaccine-derived poliovirus evolution in infants with primary B-cell immunodeficiencies and perinatal HIV exposure.
Answers are grounded in this paper and cite their sources.
Prompts vigilance for iVDPV in XLA infants with HIV exposure; leaves open transmission and evolution dynamics.
Primary B-cell immunodeficiencies are risk factors for the generation of vaccine-derived polioviruses. We report immunodeficiency-associated vaccine-derived poliovirus serotype 3 in an 11-week-old boy with X-linked agammaglobulinemia. Unique characteristics of this case include early age of presentation, high viral evolutionary rate, and the child's perinatal exposure to human immunodeficiency virus.
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Jallow et al. (2019) conducted a case report in X-linked agammaglobulinemia and perinatal HIV exposure with immunodeficiency-associated vaccine-derived poliovirus serotype 3 (n=1). Perinatal human immunodeficiency virus exposure was evaluated on Immunodeficiency-associated vaccine-derived poliovirus serotype 3 sequence evolution rate. An 11-week-old boy with X-linked agammaglobulinemia and perinatal HIV exposure presented with immunodeficiency-associated vaccine-derived poliovirus serotype 3 and a high viral evolutionary rate.
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