Vectorcardiographic Study on Left Ventricular Hypertrophy in Spontaneously Hypertensive Rats

To observe cardiac changes in spontaneously hypertensive rats (SHR) functionally, the vectrocardiographic approach was tried, applying the Takayasu lead system to rats. This vectrocardiogram (VCG) was shown to be sufficiently good to detect left ventricular hypertrophy (LVH) in SHR. VCG in SHR showed specific features, some of which were left upward deviation of the maximum QRS vector in the frontal plane, an increased magnitude of the maximum spatial QRS vector, and prolongations of such indices as the QRS duration, time to the maximum spatial QRS vector and QT interval with abnormal ST-T changes. The P wave of SHR in the X scalar electrocardiogram, lower and wider than that of Wistar-Kyoto rats may also be a significant feature of LVH in SHR. The angle of the maximum QRS vector in the horizontal plane was not proven to be a suitable index of LVH in SHR. Most of the histometrical findings were closely correlated to blood pressure. Some of the vectrocardiographic findings were significantly correlated both to blood pressure and to some of the characteristic findings of LVH, such as the weights of the heart and the left ventricle and so forth. This experiment also indicated that LVH in SHR was not limited only to quantitative myocardial hypertrophy. It also seemed to be related to reversible or irreversible qualitative changes of coronary arteries or myocardium, such as myocardial fibrosis. This vectrocardiographic method was shown to be useful in obtaining various information about the cardiovascular system in rats, especially in SHR, and it seemed to be helpful for further understanding hypertensive cardiac diseases in humans.