Key result
Deferring percutaneous coronary intervention until after transcatheter aortic valve implantation is increasingly favored due to the safety of TAVI in untreated CAD and improved coronary access.
Why the study?
The management of concomitant CAD in patients with severe aortic stenosis referred for TAVI remains a topic of debate, encompassing the evaluation and timing of PCI.
What is the optimal timing of percutaneous coronary intervention (PCI) in patients with severe aortic stenosis and concomitant coronary artery disease undergoing TAVI?
What is the optimal timing of percutaneous coronary intervention (PCI) in patients with severe aortic stenosis and concomitant coronary artery disease undergoing TAVI?
This review highlights a paradigm shift towards deferring PCI until after TAVI in patients with severe aortic stenosis and concomitant CAD, facilitated by improved TAVI techniques.
Supports deferring PCI until after TAVI in severe AS with CAD; leaves open need for RCTs to establish optimal timing.
INTRODUCTION: Patients with severe aortic stenosis referred for transcatheter aortic valve implantation (TAVI) often present with concomitant coronary artery disease (CAD). The management of CAD in these patients remains a topic of debate, encompassing the evaluation and timing of percutaneous coronary intervention (PCI). AREAS COVERED: This review article aims to offer an overview of the role of coronary revascularization in TAVI patients, highlighting the advantages and disadvantages of different strategies: PCI before, concomitant with, and after TAVI. Considering that TAVI indications are expanding and patients with low surgical risk are now being referred for TAVI, the rate of PCI among patients undergoing TAVI is expected to increase. Historically, PCI was performed before TAVI. However, there is now a growing trend to defer PCI until after TAVI. EXPERT OPINION: It is plausible that in the future, there will be an increase in PCI after TAVI due to several factors: first, multiple studies have shown the safety of TAVI even in patients with severe untreated CAD; second, improvements in TAVI device implantation techniques, such as commissural alignment and patient-specific device selection, have improved access to the coronary arteries post-TAVI.
No takes yet. Share an insight, caveat, or question.
Laterra et al. (2024) conducted a review in Severe aortic stenosis and concomitant coronary artery disease. Percutaneous coronary intervention (PCI) was evaluated. Deferring percutaneous coronary intervention until after transcatheter aortic valve implantation is increasingly favored due to the safety of TAVI in untreated CAD and improved coronary access.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: