Key result
Stable coronary heart disease was associated with higher platelet-monocyte binding compared to healthy men (27% vs 20%; P<0.05), which inversely correlated with endothelium-dependent vasodilation.
Why the study?
Is there a relationship between platelet activation and endothelium-dependent vasomotor function in patients with stable coronary heart disease?
Population
40 men (20 with stable coronary heart disease and 20 healthy controls)
Design
Cross-sectional
Authors
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Supports platelet-endothelial interaction in stable CHD; hypothesis-generating and should not yet change practice.
Case-Control (n=40)
Is there a relationship between platelet activation and endothelium-dependent vasomotor function in patients with stable coronary heart disease?
Absolute Event Rate: 27% vs 20%
p-value: p=< 0.05
There is a strong inverse relationship between markers of platelet activation and endothelium-dependent vasomotor function in patients with stable coronary heart disease, suggesting a pathophysiological link.
Robinson et al. (2006) conducted a case-control in Coronary heart disease (n=40). Stable coronary heart disease vs. Healthy men was evaluated on Platelet-monocyte binding (p=< 0.05). Stable coronary heart disease was associated with higher platelet-monocyte binding compared to healthy men (27% vs 20%; P<0.05), which inversely correlated with endothelium-dependent vasodilation.
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