Key result
Ovariectomy in female spontaneously hypertensive rats significantly increased mean circulatory filling pressure (5.9 vs 5.2 mm Hg) compared to sham operation.
Why the study?
Does ovariectomy increase venous tone in female spontaneously hypertensive rats?
Population
Five-week-old female spontaneously hypertensive rats (SHR)
Comparison
Ovariectomy (OVX) performed at 5 weeks of age vs Sham operation
Design
Preclinical
Follow-up
5 weeks (evaluated at 10 weeks of age)
Authors
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Ovarian hormones may modestly lower venous tone in hypertensive rat models; leaves open translation to human hypertension or therapy.
Does ovariectomy increase venous tone in female spontaneously hypertensive rats?
Absolute Event Rate: 5.9% vs 5.2%
Endogenous ovarian hormones appear to cause a small reduction in mean circulatory filling pressure in female spontaneously hypertensive rats, independent of adrenergic mechanisms.
Martin et al. (2008) studied Spontaneously hypertensive rats. Ovariectomy vs. Sham operation was evaluated on Mean circulatory filling pressure (MCFP). Ovariectomy in female spontaneously hypertensive rats significantly increased mean circulatory filling pressure (5.9 vs 5.2 mm Hg) compared to sham operation.
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