Key result
In rats, fasting and whole body irradiation decreased postheparin plasma clearing factor lipase activity, while intravenous injection of a crude shellac extract greatly increased its activity.
Population
Preclinical models (rats and postheparin plasma samples from four species)
Comparison
Fasting, whole body irradiation, or intravenous… vs Fed rats, pair-fed controls, or baseline/no…
Design
Preclinical
Authors
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Preclinical rat data on lipase modulation leave open human translation; hypothesis-generating for cardiovascular research.
Nutritional status, radiation, and intravenous shellac extract significantly modulate clearing factor lipase activity in postheparin plasma in rat models.
Monkhouse et al. (1961) studied this question. Fasting, whole body irradiation, and shellac injection vs. Fed rats and pair-fed controls was evaluated on Clearing factor lipase (CFL) activity. In rats, fasting and whole body irradiation decreased postheparin plasma clearing factor lipase activity, while intravenous injection of a crude shellac extract greatly increased its activity.
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