Population
Normal and alloxan diabetic rats
Comparison
Heparin injection and perfusion with… vs Normal rats; diabetic rats without insulin…
Design
Preclinical
Authors
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Insulin may normalize cardiac LPL defects in diabetes; leaves open relevance to human cardiomyopathy or therapy.
Alloxan diabetes in rats impairs the release and repletion of clearing factor lipase (lipoprotein lipase) from the heart, a defect that can be corrected by insulin treatment.
Aktin et al. (1972) studied this question.
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