What is the clinical evidence from this study?

Study design: Other. Intervention: Radiolabeled amino acids and nucleosides. Primary outcome: Biosynthetic kinetics of pituitary growth hormone forms.

March 1, 1974Endocrinology

“Large” Growth Hormone: Ribonucleic Acid-Associated Precursor of Other Growth Hormone Forms in Rat Pituitary

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Key result

Large growth hormone (LGH) is the earliest detectable biosynthetic form of pituitary GH, is associated with RNA, and acts as a precursor to small growth hormone during synthesis and secretion.

Population

Male rat anterior pituitaries

Design

Preclinical

Authors

MSMax E. StachuraUnited States Department of Veterans Affairs LFLawrence A. FrohmanDartmouth College

Discussion

Member takes

Implication

No change to clinical GH management; leaves open LGH precursor role in human pituitary synthesis.

Structured PICO

Population

Male rat anterior pituitaries used to study the biosynthesis and kinetics of growth hormone forms.

Intervention

Incubation with 14C and 3H-labeled amino acids or nucleosides, extraction, Sephadex G-200 filtration, and ribonuclease treatment

Outcome

Identification and sequential relationship of biosynthetic forms of pituitary growth hormone (LGH, SGH, and intermediate forms)surrogate

Large growth hormone (LGH) is the earliest detectable biosynthetic precursor of pituitary growth hormone in rats and is associated with RNA.

Cite This Study

Stachura et al. (1974) studied this question. Radiolabeled amino acids and nucleosides was evaluated on Biosynthetic kinetics of pituitary growth hormone forms. Large growth hormone (LGH) is the earliest detectable biosynthetic form of pituitary GH, is associated with RNA, and acts as a precursor to small growth hormone during synthesis and secretion.

synapsesocial.com/papers/6a9b053b84d07ee2fcd15f84 https://doi.org/10.1210/endo-94-3-701

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March 1, 1974Endocrinology

“Large” Growth Hormone: Ribonucleic Acid-Associated Precursor of Other Growth Hormone Forms in Rat Pituitary

View Full Paper

Ask AI

Bookmark

Key result

Large growth hormone (LGH) is the earliest detectable biosynthetic form of pituitary GH, is associated with RNA, and acts as a precursor to small growth hormone during synthesis and secretion.

Population

Male rat anterior pituitaries

Design

Preclinical

Authors

MSMax E. StachuraUnited States Department of Veterans Affairs LFLawrence A. FrohmanDartmouth College

Discussion

Member takes

Implication

No change to clinical GH management; leaves open LGH precursor role in human pituitary synthesis.

Structured PICO

Population

Male rat anterior pituitaries used to study the biosynthesis and kinetics of growth hormone forms.

Intervention

Incubation with 14C and 3H-labeled amino acids or nucleosides, extraction, Sephadex G-200 filtration, and ribonuclease treatment

Outcome

Identification and sequential relationship of biosynthetic forms of pituitary growth hormone (LGH, SGH, and intermediate forms)surrogate

Large growth hormone (LGH) is the earliest detectable biosynthetic precursor of pituitary growth hormone in rats and is associated with RNA.

Cite This Study

synapsesocial.com/papers/6a9b053b84d07ee2fcd15f84 https://doi.org/10.1210/endo-94-3-701

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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