Key result
An 80-year-old man with metastatic urothelial carcinoma developed fatal cardiac tamponade due to myocardial rupture caused by a metastatic nodule penetrating the right anterior ventricular wall.
Case Report (n=1)
This case highlights that metastatic urothelial carcinoma can rarely cause myocardial rupture and fatal cardiac tamponade.
Answers are grounded in this paper and cite their sources.
Alerts clinicians to rare fatal tamponade from urothelial cardiac metastases; hypothesis-generating and should not change practice.
major causes of cardiac metastasis are lung cancer, breast cancer, hematologic malignancies, and malignant melanoma, 2 a few cases derived from urothelial carcinoma have been reported. 3,4 Most cardiac metastases are with widely metastatic conditions in late-stage cancer, and are often clinically silent. 2 Thus, they tend to be diagnosed on postmortem examination. They should always be taken into consideration, however, when treating cancer patients with cardiac symptoms, because radiotherapy, chemotherapy, or catheterization would be useful tools for palliative and/or life-prolonging treatment in some cases. 1,2
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Sugimoto et al. (2018) conducted a case report in Myocardial rupture due to metastatic urothelial carcinoma (n=1). Metastatic urothelial carcinoma was evaluated. An 80-year-old man with metastatic urothelial carcinoma developed fatal cardiac tamponade due to myocardial rupture caused by a metastatic nodule penetrating the right anterior ventricular wall.
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