Key result
Low-dose indapamide (1 mg) significantly reduced blood pressure from 162/85 mmHg to 134/71 mmHg when given daily, and maintained this reduction when given every other day.
Why the study?
Does low-dose indapamide given daily or every-other-day reduce blood pressure without causing metabolic derangements in hypertensive patients?
Does low-dose indapamide given daily or every-other-day reduce blood pressure without causing metabolic derangements in hypertensive patients?
Absolute Event Rate: 134% vs 162%
p-value: p=<0.001
Low-dose indapamide (1 mg) given every-other-day maintains the blood pressure reduction achieved by daily dosing while avoiding the mild hyperuricemia associated with daily use.
May support every-other-day dosing to limit hyperuricemia; leaves open confirmation in randomized outcome trials.
To investigate the effects of the diuretic, indapamide, on blood pressure (BP) and metabolic parameters, thirty hypertensive patients were treated with 1 mg of indapamide either every day or every other day. BP, fasting plasma glucose, lipids, serum potassium and uric acid were determined at baseline and after 3 months of a stable regimen of the drug. At the termination of the study, 48-h ambulatory blood pressure monitoring (ABPM) was performed. Three patients received only indapamide, while other patients were treated in combination with additional antihypertensive medications. Patients treated with daily indapamide showed a BP reduction from 162 +/- 2.9/85 +/- 2.4 mmHg to 134 +/- 2.4/71 +/-2.6 mmHg (p < 0.001). The BP reduction was similar in those patients receiving the drug every other day (137 +/- 3.4/71 +/- 3.6 mmHg). While plasma lipids and serum potassium did not differ significantly with the intervention, uric acid increased significantly with daily treatment and normalized with every-other-day treatment. Glycosylated hemoglobin A1c (HbA1c) was not altered (5.6 +/- 0.1% vs. 5.4 +/- 0.2%), and did not differ between patients with and without diabetes mellitus. ABPM revealed an average 24-h BP of 134 +/- 3.3/75 +/- 1.7 mmHg on days in which patients received the medication and 139 +/- 4.9/78 +/- 2.6 mmHg on the intervening day without indapamide (no significant difference). These results suggest that a low dose of indapamide given every day or every other day is effective in lowering BP and does not result in metabolic derangements.
No takes yet. Share an insight, caveat, or question.
Inaba et al. (2004) studied Hypertension (n=30). Indapamide vs. Baseline was evaluated on Systolic blood pressure (p=<0.001). Low-dose indapamide (1 mg) significantly reduced blood pressure from 162/85 mmHg to 134/71 mmHg when given daily, and maintained this reduction when given every other day.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: