Key result
Acute childhood infection was associated with impaired endothelial function, with lower flow-mediated dilation in the acute infection group compared to healthy controls (6.3% vs 9.7%; P<0.001).
Why the study?
Does acute childhood infection impair endothelial function compared to healthy controls?
Population
600 children aged 10 years drawn from the Avon Longitudinal Study of Parents and Children
Comparison
Current acute infection or convalescent from… vs Healthy control group (n=299)
Design
Cohort
Follow-up
mean interval of 1 year (for a subset)
Authors
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May warrant no change in pediatric infection care; hypothesis-generating for inflammation's role in early atherogenesis.
Observational (n=600)
Does acute childhood infection impair endothelial function compared to healthy controls?
Absolute Event Rate: 6.3% vs 9.7%
p-value: p=<0.001
Acute childhood infection is associated with transiently impaired endothelium-dependent vasodilation, suggesting a role for inflammatory stimuli in early atherogenesis.
Charakida et al. (2005) conducted an observational in Acute infection (n=600). Acute infection vs. Healthy controls was evaluated on Brachial artery flow-mediated dilation (FMD) (p=<0.001). Acute childhood infection was associated with impaired endothelial function, with lower flow-mediated dilation in the acute infection group compared to healthy controls (6.3% vs 9.7%; P<0.001).
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