Key result
Gonadal white adipose tissue-derived exosomal miR-222 promotes obesity-associated insulin resistance in the liver and skeletal muscle by directly suppressing IRS1 expression.
Why the study?
The study investigated the role of serum exosomal miR-222 in obesity-related insulin resistance.
Gonadal white adipose tissue-derived exosomal miR-222 promotes obesity-associated insulin resistance by suppressing IRS1 expression in liver and skeletal muscle.
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May link adipose exosomal miR-222 to insulin resistance in mice; hypothesis-generating for human metabolic disease.
Li et al. (2020) studied Obesity-associated insulin resistance. Gonadal white adipose tissue-derived exosomal miR-222 vs. Normal chow diet / healthy controls was evaluated on Insulin sensitivity and IRS1 protein expression in liver and skeletal muscle. Gonadal white adipose tissue-derived exosomal miR-222 promotes obesity-associated insulin resistance in the liver and skeletal muscle by directly suppressing IRS1 expression.
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