Key result
Prophylactic DeVega tricuspid annuloplasty during orthotopic heart transplantation significantly increased the incidence of right bundle branch block (37.1% vs 9.4%) compared to no annuloplasty.
Why the study?
Does prophylactic DeVega tricuspid annuloplasty increase the risk of conduction abnormalities or improve hemodynamics in adult cardiac transplant recipients?
Cohort (n=180)
No
Does prophylactic DeVega tricuspid annuloplasty increase the risk of conduction abnormalities or improve hemodynamics in adult cardiac transplant recipients?
Absolute Event Rate: 37.1% vs 9.4%
p-value: p=<0.001
Prophylactic DeVega tricuspid annuloplasty during orthotopic heart transplantation is associated with a significantly increased risk of early conduction abnormalities, including complete heart block requiring pacing, without providing significant long-term hemodynamic benefits.
May increase post-transplant conduction risks without TR benefit; hypothesis-generating and should not yet change practice.
Prophylactic DeVega tricuspid annuloplasty (DVA) of the donor heart has been reported to improve tricuspid regurgitation (TR), renal dysfunction, and mortality in cardiac transplant recipients. This is the first study to investigate the electrical, as well as, hemodynamic effects of DVA during orthotopic heart transplantation (OHT). Electrocardiographic, echocardiographic, and hemodynamic data of 76 patients with DVA and 104 patients without DVA who underwent OHT between 2013 and 2017 at Columbia University Medical Center (New York, NY) were studied. Patients with DVA were older (56.5 ± 1.2 vs. 52.4 ± 1.0 years of age; p = 0.017) and predominantly men (78% vs. 68%; p = 0.02). There were no significant differences in right ventricular function and TR. Patients with DVA had increased incidence of right bundle branch block compared with without DVA (37% ± 5.9% vs. 9% ± 2.9%; p < 0.001). Three patients with DVA developed complete heart block (CHB), whereas no patients without DVA developed CHB (p = 0.04). Four patients with DVA received a pacemaker (PPM), whereas only one patient in the without DVA group received a PPM. Complete heart block was significantly increased in patients who received prophylactic DVA. Possible risk of conduction abnormalities should be considered with performance of DVA annuloplasty in cardiac transplant recipients.
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Rubin et al. (2018) conducted a cohort in End-stage heart failure requiring orthotopic heart transplantation (n=180). Prophylactic DeVega tricuspid annuloplasty vs. No DeVega tricuspid annuloplasty was evaluated on Incidence of right bundle branch block during the first postoperative week (p=<0.001). Prophylactic DeVega tricuspid annuloplasty during orthotopic heart transplantation significantly increased the incidence of right bundle branch block (37.1% vs 9.4%) compared to no annuloplasty.
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