August 1, 2000Arteriosclerosis Thrombosis and Vascular Biology
Blood Pressure, LDL Cholesterol, and Intima-Media Thickness
Key result
Elevated LDL cholesterol was associated with increased carotid intima-media thickness in the upper tertile of systolic blood pressure (beta=0.025; P=0.002), but not in lower tertiles.
Why the study?
Is the association between LDL cholesterol and carotid intima-media thickness dependent on systolic blood pressure levels in adults without symptomatic cardiovascular disease?
Population
511 adults aged 40 to 60 years, free of symptomatic cardiovascular disease at recruitment, from the Los…
Comparison
LDL-C levels within the high tertile of systolic… vs LDL-C levels within the middle and low tertiles…
Design
Cohort
Authors
Discussion
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Implication
May indicate SBP modifies LDL effect on cIMT; hypothesis-generating and should not change practice.
Study Design
Type
Cohort (n=576)
Structured PICO
Is the association between LDL cholesterol and carotid intima-media thickness dependent on systolic blood pressure levels in adults without symptomatic cardiovascular disease?
P
Population
511 analyzed adults aged 40 to 60 years without symptomatic cardiovascular disease, evaluated for the association between LDL cholesterol, systolic blood pressure, and carotid intima-media thickness.
E
Exposure
LDL-C levels within the high tertile of systolic blood pressure (133 to 175 mm Hg)
C
Comparator
LDL-C levels within the middle (123 to 132 mm Hg) and low (93 to 122 mm Hg) tertiles of systolic blood pressure
O
Outcome
Common carotid artery intima-media thickness (IMT) assessed by B-mode ultrasonographysurrogate
Main Result
Effect estimate: beta 0.025
p-value: p=0.002
Elevated LDL cholesterol is associated with increased carotid intima-media thickness only in individuals with higher systolic blood pressure, supporting the hypothesis that hypertension-induced arterial injury precedes LDL-mediated atherogenesis.
Cite This Study
Sun et al. (2000) conducted a cohort in Atherosclerosis risk (n=576). LDL cholesterol was evaluated on Common carotid artery intima-media thickness (IMT) (beta 0.025, p=0.002). Elevated LDL cholesterol was associated with increased carotid intima-media thickness in the upper tertile of systolic blood pressure (beta=0.025; P=0.002), but not in lower tertiles.