Key result
Intravenous paracetamol was ineffective as rescue therapy for ibuprofen-resistant hemodynamically significant patent ductus arteriosus in 3 preterm infants, with all requiring surgical ligation.
Why the study?
Does intravenous paracetamol prevent surgical ligation in preterm infants with ibuprofen-resistant hsPDA?
Population
3 preterm infants with hemodynamically significant patent ductus arteriosus who failed prior intravenous…
Design
Case_series
Authors
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Does not support IV paracetamol rescue for ibuprofen-resistant hsPDA; hypothesis-generating and should not yet change practice.
Case Report (n=3)
Does intravenous paracetamol prevent surgical ligation in preterm infants with ibuprofen-resistant hsPDA?
In this small case series, intravenous paracetamol was ineffective as a rescue therapy for ibuprofen-resistant hsPDA and was associated with elevated liver enzymes, suggesting NSAIDs should remain the first choice.
Alan et al. (2013) conducted a case report in hemodynamically significant patent ductus arteriosus (hsPDA) (n=3). Intravenous paracetamol was evaluated on Surgical ligation. Intravenous paracetamol was ineffective as rescue therapy for ibuprofen-resistant hemodynamically significant patent ductus arteriosus in 3 preterm infants, with all requiring surgical ligation.
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