Key result
Elevated left ventricular end-diastolic pressure was associated with a higher 1-year rate of all-cause mortality or heart failure admission compared to the lowest quartile.
Why the study?
Prior studies linking elevated LVEDP to adverse STEMI outcomes were retrospective post hoc analyses from the thrombolysis or early primary PCI era, leaving its prognostic value in contemporary primary PCI practice unclear.
Does elevated LVEDP predict the composite of 12-month all-cause mortality and heart failure admissions in STEMI patients undergoing primary PCI?
Cohort (n=997)
No
Does elevated LVEDP predict the composite of 12-month all-cause mortality and heart failure admissions in STEMI patients undergoing primary PCI?
Answers are grounded in this paper and cite their sources.
Elevated LVEDP is an independent predictor of 1-year all-cause mortality and heart failure admissions in STEMI patients undergoing contemporary primary PCI, even with relatively normal LVEF.
OBJECTIVES: Elevated left ventricular end-diastolic pressure (LVEDP) in ST-segment elevation myocardial infarction (STEMI) has been studied in patients who received thrombolysis or who were treated early in the primary percutaneous coronary intervention (PCI) era; LVEDP was found to be a predictor of adverse outcomes in these retrospective post hoc analyses. The aim of the current analysis is to assess the prognostic value of the elevated LVEDP in STEMI patients undergoing primary PCI in current contemporary practice. DESIGN: Prospective, single-centre study. PARTICIPANTS: Our study enrolled STEMI patients with elevated LVEDP undergoing primary PCI at John Hunter Hospital, Newcastle, Australia. PRIMARY OUTCOME MEASURE: The primary endpoint was the combination of 12-month all-cause mortality and heart failure admissions, comparing different quartiles of LVEDP. RESULTS: A total of 997 patients underwent primary PCI at our hospital during the 5-year study period (age: 64±13 years, males: 73%; n=728) from 1 January 2015 to 31 December 2019. The median LVEDP for the whole cohort was 27 mm Hg (IQR: 22-31 mm Hg). The median LVEDP was 17 mm Hg (IQR: 13-18 mm Hg) and 33 mm Hg (IQR: 30-36 mm Hg) for 1st and 4th quartiles respectively (p<0.01). At 1 year, the composite endpoint of all-cause mortality or heart failure admission was 12% vs 26% (p=0.01) in quartiles 1 and 4 respectively. The mean left ventricular ejection fraction (LVEF) for the whole cohort was 50%. In multivariate regression analysis, age, anterior STEMI, out of hospital cardiac arrest and LVEDP quartile 4 were independent predictors of mortality; LVEF was not. CONCLUSIONS: LVEDP is an independent predictor of adverse outcomes in STEMI patients, despite a relatively normal LVEF. Further prospective studies are needed to assess the effects of early reduction in LVEDP on the prognosis.
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Khan et al. (2025) conducted a cohort in ST-elevation myocardial infarction (n=997). Elevated left ventricular end-diastolic pressure (Quartile 4) vs. Lowest quartile of LVEDP (Quartile 1) was evaluated on Combination of 12-month all-cause mortality and heart failure admissions (p=0.01). Elevated left ventricular end-diastolic pressure was associated with a higher 1-year rate of all-cause mortality or heart failure admission compared to the lowest quartile.
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