Key result
Intracoronary injection of bupivacaine resulted in a 25% longer duration of myocardial depression compared to lidocaine for an equal degree of depression (P<0.05).
Why the study?
Does intracoronary bupivacaine cause greater magnitude or duration of direct myocardial depression compared to lidocaine?
Population
Preclinical model undergoing direct injection into a branch of the left coronary artery
Comparison
Intracoronary injection of small bolus doses of… vs Intracoronary injection of small bolus doses of…
Design
Preclinical
Authors
Loading...
Longer bupivacaine-induced myocardial depression in this animal model; leaves open whether direct effects explain clinical cardiotoxicity differences.
Does intracoronary bupivacaine cause greater magnitude or duration of direct myocardial depression compared to lidocaine?
Effect estimate: 25% longer
p-value: p=<0.05
The magnitude and duration of direct myocardial depression are similar between bupivacaine and lidocaine when adjusted for dose, suggesting other mechanisms explain bupivacaine's greater clinical cardiovascular toxicity.
Charles W. Buffington (1989) studied Direct myocardial depression. Lidocaine and bupivacaine vs. Lidocaine vs bupivacaine was evaluated on Duration of myocardial depression (time for 95% recovery of systolic contraction) (25% longer, p=<0.05). Intracoronary injection of bupivacaine resulted in a 25% longer duration of myocardial depression compared to lidocaine for an equal degree of depression (P<0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: