Key result
Dyslipidemia in children is a crucial trigger for endothelial dysfunction and cardiovascular morphological changes, requiring aggressive management to prevent future cardiac disease.
Dyslipidemia in childhood contributes to early atherosclerotic changes and cardiovascular morphological alterations, highlighting the need for aggressive management to prevent adult cardiac disease.
Dyslipidemia may initiate endothelial dysfunction in at-risk children; leaves open whether lipid intervention alters stiffness or carotid IMT.
PURPOSE OF REVIEW: In this review, we firstly highlight the role of dyslipidemia as a trigger in the initiation and progression of endothelial dysfunction, considered the earliest atherosclerotic lesion and patent in children with risk factors.In this context, we also revise methods that reflect the impact of endothelial dysfunction not only on arterial stiffness but also on cardiovascular morphology, namely, the common carotid intima-media thickness and the ventricular geometry. RECENT FINDINGS: In view of its atherogenic burden, the most widely studied lipoprotein has been low density lipoprotein cholesterol. However, the smaller, denser, low density lipoprotein cholesterol particles, the nonhigh density lipoprotein cholesterol fraction, appear to be more atherogenic and a more sensitive cardiovascular risk marker. Studies have shown that in children, atherogenic lipids have also been linked to cardiovascular morphological changes, such as the common carotid intima-media thickness and the ventricular geometry, both independent cardiovascular risk markers. SUMMARY: In infancy, atherosclerosis is a preclinical disorder in which dyslipidemia plays a crucial role. Due to its impact on cardiovascular structures, potentially reversible during childhood, dyslipidemia ought to be managed aggressively to prevent further disease progression that will ultimately culminate in cardiac disease, a leading cause of mortality in adults.
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Pires et al. (2015) conducted a review in Dyslipidemia. Dyslipidemia was evaluated. Dyslipidemia in children is a crucial trigger for endothelial dysfunction and cardiovascular morphological changes, requiring aggressive management to prevent future cardiac disease.
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