Key result
Various in vivo and in vitro experimental models are utilized to study hypertension and evaluate antihypertensive agents, though translating these animal model findings to human hypertension remains challenging.
Why the study?
The authors aimed to evaluate the use of specific antihypertensive drugs, drug classes, and combinations across categories of resistant hypertension, controlled versus uncontrolled resistant hypertension, and true versus white-coat resistant hypertension.
Answers are grounded in this paper and cite their sources.
This article reviews various experimental animal models used in hypertension research, highlighting the complexity of translating preclinical findings to human primary hypertension.
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Jaybhaye et al. (2022) conducted a review in Hypertension (n=21,238). Antihypertensive agents was evaluated. Various in vivo and in vitro experimental models are utilized to study hypertension and evaluate antihypertensive agents, though translating these animal model findings to human hypertension remains challenging.
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