Key result
COX-2 activity suppressed GM-CSF, but not IL-8, release by human vascular smooth muscle cells via a cAMP-dependent pathway.
Population
Human arterial and venous vascular smooth muscle cells
Design
Preclinical
Authors
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Hypothesis-generating for vascular inflammation control; leaves open relevance to human atherosclerosis progression.
COX-2 activity suppresses GM-CSF release via a cAMP-dependent pathway in human vascular cells, illustrating a novel mechanism for modulating immune and inflammatory events.
Stanford et al. (2000) studied this question. COX-2 activity was evaluated on GM-CSF and IL-8 release. COX-2 activity suppressed GM-CSF, but not IL-8, release by human vascular smooth muscle cells via a cAMP-dependent pathway.
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