Key result
Review highlights mechanisms regulating vasa vasorum tone and their functional impact in cardiovascular disease.
This review highlights the mechanisms regulating vasa vasorum tone and their potential role in cardiovascular diseases such as atherosclerosis.
Vasa vasorum tone may influence atherosclerosis; leaves open targeted interventions pending prospective trials.
The walls of conduit blood vessels are nourished by diffusion of oxygen from luminal blood and from the vasa vasorum. The vasa vasorum, or 'vessels of a vessel', form a network of microvessels that lie in the adventitia and penetrate the outer media of the host vessel wall. Although the importance of the vasa vasorum in providing nutritional support is not well defined, obstruction of blood flow through these vessels has been implicated in the pathogenesis of certain cardiovascular diseases including atherosclerosis. This review focuses on the mechanisms that regulate tone in the vasa vasorum of large arteries and the functional implications of changes in reactivity of vasa vasorum.
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Robert W. Scotland (2000) conducted a review in Cardiovascular diseases including atherosclerosis. Endogenous factors regulating tone of arterial vasa vasorum was evaluated. This review highlights the mechanisms regulating tone in the vasa vasorum of large arteries and the functional implications of changes in their reactivity in cardiovascular diseases.
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