Key result
In patients undergoing CABG surgery, acadesine decreased the incidence of perioperative myocardial infarction by 27% compared to placebo (OR 0.69; 95% CI 0.51-0.95; P=.02).
Why the study?
Does acadesine reduce perioperative myocardial infarction and cardiovascular complications in patients undergoing CABG surgery?
Meta-Analysis (n=4,043)
double-blind
randomized
Yes
Does acadesine reduce perioperative myocardial infarction and cardiovascular complications in patients undergoing CABG surgery?
Odds Ratio: 0.69 (95% CI 0.51–0.95)
p-value: p=.02
Acadesine administered before and during CABG surgery significantly reduces the risk of perioperative myocardial infarction and early cardiac death.
No takes yet. Share an insight, caveat, or question.
Supports acadesine in CABG to lower perioperative MI risk; confirms benefit across pooled trials.
Dennis T. Mangano (1997) conducted a meta-analysis in coronary artery bypass graft (CABG) surgery (n=4,043). acadesine vs. placebo was evaluated on perioperative myocardial infarction (MI) (OR 0.69, 95% CI 0.51-0.95, p=.02). In patients undergoing CABG surgery, acadesine decreased the incidence of perioperative myocardial infarction by 27% compared to placebo (OR 0.69; 95% CI 0.51-0.95; P=.02).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: