Key result
The combination of methyldopa and hydrochlorothiazide produced a significantly greater decrease in standing mean arterial pressure than did either drug alone.
Why the study?
Does the combination of methyldopa and hydrochlorothiazide reduce blood pressure more effectively than either drug alone in patients with primary hypertension?
RCT (n=45)
randomized
Does the combination of methyldopa and hydrochlorothiazide reduce blood pressure more effectively than either drug alone in patients with primary hypertension?
The combination of methyldopa and hydrochlorothiazide is more effective at reducing standing mean arterial pressure than either agent alone in patients with primary hypertension.
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Supports combination therapy over monotherapy for hypertension; confirms additive BP reduction in this RCT.
William R. Wilson (1963) conducted an RCT in Primary Hypertension (n=45). Methyldopa and hydrochlorothiazide vs. Methyldopa alone or hydrochlorothiazide alone was evaluated on Supine and standing mean arterial pressure. The combination of methyldopa and hydrochlorothiazide produced a significantly greater decrease in standing mean arterial pressure than did either drug alone.
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