Key result
Clonidine-chlorthalidone improves morning diastolic BP control over methyldopa-chlorthalidone, but causes more side effects.
Why the study?
The comparative hypotensive efficacy and side effect profiles of clonidine-chlorthalidone versus methyldopa-chlorthalidone combinations in hypertension treatment were unclear.
Does clonidine-chlorthalidone improve blood pressure reduction compared to methyldopa-chlorthalidone in patients with hypertension?
RCT
Open-label
cross-over
Does clonidine-chlorthalidone improve blood pressure reduction compared to methyldopa-chlorthalidone in patients with hypertension?
Clonidine-chlorthalidone is more effective than methyldopa-chlorthalidone at reducing diastolic blood pressure in hypertensive patients, but is associated with a higher incidence of side effects.
Answers are grounded in this paper and cite their sources.
Clonidine-chlorthalidone may control BP better than methyldopa-chlorthalidone yet with more side effects; leaves open optimal modern combinations.
In an open, randomized, cross-over study the hypotensive action and side effects of clonidine-chlorthalidone and methyldopa-chlorthalidone combinations were compared. The diastolic morning blood pressure could be reduced to 95 mm. Hg or below in significantly more patients with clonidine than with methyldopa. Side effects, however, were more commonly encountered during the clonidine than during the methyldopa phase.
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Amery et al. (1970) conducted an RCT in Hypertension. Clonidine-chlorthalidone vs. Methyldopa-chlorthalidone was evaluated on Reduction of diastolic morning blood pressure to 95 mm Hg or below. Clonidine-chlorthalidone reduced diastolic morning blood pressure to 95 mm Hg or below in significantly more patients than methyldopa-chlorthalidone, but caused more side effects.
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