Why the study?
Does a single evening dose of clonidine-chlorthalidone combination maintain adequate blood pressure control compared to a twice-daily schedule in patients with essential hypertension?
Does a single evening dose of clonidine-chlorthalidone combination maintain adequate blood pressure control compared to a twice-daily schedule in patients with essential hypertension?
A single daily evening dose of clonidine-chlorthalidone may provide adequate blood pressure control comparable to a twice-daily schedule in some patients with essential hypertension.
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May support simplified once-daily dosing in select patients; leaves open confirmation in randomized trials.
A single evening dose of a clonidine-chlorthalidone combination (Combipres) was compared with the usual twice-daily schedule in 11 patients with essential hypertension. No significant difference was found between the blood pressures recorded on the two regimens or between morning and afternoon pressures on the once-daily schedule. Only one patient did not maintain adequate blood pressure control. We suggest that some patients with essential hypertension can be adequately treated with a single daily dose of a combination of clonidine and chlorthalidone.
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Grossman et al. (1980) studied this question.
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