Why the study?
Does clonidine in a b.i.d. schedule 150-300 micrograms daily reduce blood pressure in patients with essential hypertension?
Does clonidine in a b.i.d. schedule 150-300 micrograms daily reduce blood pressure in patients with essential hypertension?
Clonidine administered twice daily at 150-300 micrograms effectively reduces blood pressure and maintains therapeutic plasma concentrations in patients with essential hypertension.
Answers are grounded in this paper and cite their sources.
Supports b.i.d. clonidine for hypertension; hypothesis-generating pending randomized confirmation.
The therapeutic efficacy of clonidine as an antihypertensive in a b.i.d. schedule 150--300 micrograms daily was evaluated. The blood pressure reduction in patients with essential hypertension was satisfactory on this regimen and the steady-state plasma concentrations were within the BP-lowering concentration range at the end of a dosage interval.
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Marianne Frisk‐Holmberg (1980) studied this question.
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