Key result
Ketoconazole was entirely responsible for QTc interval prolongation in conscious guinea-pigs, with no additional effects from subsequent administration of ebastine, terfenadine, or loratadine.
Why the study?
Does ketoconazole alter the QTc interval prolonging effects of H1-antihistamines in a guinea-pig model?
Does ketoconazole alter the QTc interval prolonging effects of H1-antihistamines in a guinea-pig model?
In a guinea-pig model, QTc prolongation previously attributed to certain H1-antihistamines when co-administered with ketoconazole is actually caused entirely by ketoconazole itself.
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QTc prolongation previously attributed to H1-antihistamines with ketoconazole is ketoconazole-driven in guinea-pigs; challenges interaction assumptions and leaves open human translation.
Gras et al. (1996) studied Arrhythmogenicity. Ketoconazole and H1-antihistamines (ebastine, terfenadine, loratadine) was evaluated on QTc interval prolongation. Ketoconazole was entirely responsible for QTc interval prolongation in conscious guinea-pigs, with no additional effects from subsequent administration of ebastine, terfenadine, or loratadine.
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