Key result
Specific histological subtypes, deep location, larger tumor size, and high histological grade were associated with a higher incidence of liver metastasis at initial presentation (overall 3.2%).
Why the study?
Noncontrast computed tomography of the chest is standard for cancer staging in soft tissue sarcoma, but appropriate candidates for liver screening have not been clarified.
What are the incidence and risk factors for liver metastasis at initial presentation in patients with soft tissue sarcoma?
Observational (n=47,260)
Yes
What are the incidence and risk factors for liver metastasis at initial presentation in patients with soft tissue sarcoma?
Specific histological subtypes, deep location, trunk development, larger tumor size, and high histological grade are significant risk factors for liver metastasis at initial presentation in soft tissue sarcoma, which may help identify appropriate candidates for liver screening.
May inform selective liver screening in high-risk soft tissue sarcoma subtypes; leaves open whether detection improves outcomes.
BACKGROUND AND OBJECTIVES: Noncontrast computed tomography of the chest is the standard imaging modality for cancer staging in patients with soft tissue sarcoma (STS), but appropriate candidates for liver screening have not been clarified. METHODS: We reviewed all patients with STS diagnosed between 2010 and 2018 in the Surveillance, Epidemiology, and End Results database. Incidence of liver metastasis at initial presentation and high incidence of liver metastasis by histological subtype were investigated. In addition, risk factors for liver metastasis were investigated by multiple logistic regression analysis. RESULTS: After excluding patients without information about liver metastasis, cause of death or primary liver tumor, 47 260 patients were included in this study. Of those, 1471 patients (3.2%) showed liver metastasis at initial presentation. The histological subtype showing the highest incidence of liver metastasis was desmoplastic small round cell tumor (30.3%), followed by malignant hemangioendothelioma (11.5%) and angiomyoliposarcoma (10.5%). Deep-rooted tumor, location in the body wall, retroperitoneum, or thorax/peritoneum, high histological grade, and higher T stage were associated with higher incidences of liver metastasis at initial presentation. CONCLUSION: Risk factors for liver metastasis were deep location, trunk development, larger tumor size, high histological grade, and specific histological subtypes.
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Kawae et al. (2022) conducted an observational in Soft tissue sarcoma (n=47,260). Histological subtype and tumor characteristics was evaluated on Incidence of liver metastasis at initial presentation. Specific histological subtypes, deep location, larger tumor size, and high histological grade were associated with a higher incidence of liver metastasis at initial presentation (overall 3.2%).
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