Key result
Failing and hypertrophic hearts showed no differences in Troponin T and I isoform expression compared with normal adult hearts, whereas an isoform switch occurs from fetal to adult forms.
Authors
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Questions fetal troponin isoform re-expression in cardiomyopathy; leaves open its role in disease progression.
Observational (n=30)
Kim et al. (1998) conducted an observational in Failing, hypertrophic, normal, and fetal hearts (n=30). Heart failure and hypertrophy vs. Normal adult and fetal hearts was evaluated on Isoform expression of TnT & TnI. Failing and hypertrophic hearts showed no differences in Troponin T and I isoform expression compared with normal adult hearts, whereas an isoform switch occurs from fetal to adult forms.
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